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KMID : 0603820090150030257
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Journal of Experimental & Biomedical Science
2009 Volume.15 No. 3 p.257 ~ p.260
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Oak Wood Vinegar Suppresses the Expression of Cyclooxygenase-2 Induced by TLR4 Agonist
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Yun Sae-Mi
Youn Hyung-Sun
Ahn Sang-Il
Lee A-Neum
Park Se-Jeong
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Abstract
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Toll-like receptors (TLRs) recognize molecular structures derived from microbes including bacteria, viruses, yeast, and fungi. TLRs have emerged as a major signaling component of the mammalian host defense. TLR4 is a member of the Toll family that senses lipopolysaccharide (LPS), a cell wall component of gram negative bacteria. LPS recognition by TLR4 requires an additional accessory molecule, MD-2. LPS induces the activation of NF-κB and IRF3 through MyD88 or TRIF-dependent pathways. The activation of NF-κB leads to the induction of inflammatory gene products including cytokines and cyclooxygenase-2 (COX-2). This study was carried out to investigate the anti-inflammatory effects of oak wood vinegar. Oak wood vinegar inhibits the NF-κB activation and COX-2 expression induced by LPS. These results provide new ideas to understand the mechanism of oak wood vinegar for its anti-bacterial and anti-inflammatory activities.
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KEYWORD
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Toll-like receptors, Oak wood vinegar, Lipopolysaccharide, NF-κB, Cyclooxygenase-2
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